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天麻炮制及其标准饮片的均匀化工艺研究
高笑笑1, 李霞1, 苗静1, 宋嬿2, 张玉莲2, 吕婷婷2, 高文远1
1.天津大学药物科学与技术学院, 天津 300072;2.上海上药华宇药业有限公司科研管理部, 上海 200002
摘要:
[目的]优选天麻的炮制工艺及其标准饮片的均匀化工艺。[方法]分析影响炮制和均匀化工艺的因素,在此基础上设计正交试验,分别以天麻素和对羟基苯甲醇总含量及总多糖含量、天麻素和对羟基苯甲醇总含量及出粉率为指标,综合优选出最佳炮制工艺和均匀化工艺。[结果]最佳润切工艺为:浸泡54 h,闷润22 h,切片后于60℃烘干;最佳蒸切工艺为:浸泡3 h,蒸制3 h,切片后于40℃烘干;最佳均匀化工艺:单次粉碎时间为15 s,粉碎3次,投料量占粉碎机总体积的3/4。[结论]通过验证实验证明优选出的最佳工艺稳定、合理、可行,可为天麻饮片的规范化研究提供参考。
关键词:  天麻  标准饮片  炮制工艺  均匀化工艺  正交试验
DOI:10.11656/j.issn.1673-9043.2018.06.14
分类号:R284.3
基金项目:国家发展改革委、中医药管理局中药标准化项目(ZYBZH-Y-SH-38);科技部基础性工作专项(2014FY111100)。
Study on processing technology of Gastrodia elata Bl and homogenization technology of its standard pieces
GAO Xiaoxiao1, LI Xia1, MIAO Jing1, SONG Yan2, ZHANG Yulian2, LV Tingting2, GAO Wenyuan1
1.School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;2.Research management department, Shanghai shangyao Huayu pharmaceutical co., ltd, Shanghai 200002, China
Abstract:
[Objective] To investigate the optimal processing technology of Gastrodia elata Bl and the optimal homogenization technology of its standard pieces.[Methods] The factors that affect the processing and homogenization technology were analyzed, orthogonal tests were designed on this basis. The total content of gastrodin and p-hydroxybenzyl alcohol and the content of polysaccharide, the total content of gastrodin and p-hydroxybenzyl alcohol and flour yield were as indexes to optimize the processing technology and homogenization technology, respectively.[Results] The optimized conditions of moistened pieces were soaking in water for 54 h, moistening for 22 h, slicing and drying at 60℃; The optimized conditions of steamed pieces were soaking in water for 3 h, steaming for 3 h, slicing and drying at 40℃; the optimal homogenization technology was selected as follows:3/4 volume of the pulverizer, running 15 s for 3 times.[Conclusion] The optimized technologies had been proved stable, reasonable and feasible through verification tests. And it provided a certain reference for the research of the standardization of Gastrodia elata Bl pieces.
Key words:  Gastrodia elata B1  standardized pieces  processing technology  homogenization technology  orthogonal test
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